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1. (WO2018027123) MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/027123    International Application No.:    PCT/US2017/045479
Publication Date: 08.02.2018 International Filing Date: 04.08.2017
IPC:
A61K 39/385 (2006.01), A61K 39/39 (2006.01), A61K 39/09 (2006.01), A61K 31/70 (2006.01), A61P 31/04 (2006.01), A61P 37/04 (2006.01)
Applicants: SANOFI PASTEUR, INC. [US/US]; 1 Discovery Drive Swiftwater, PA 18730 (US).
SK CHEMICALS CO., LTD. [KR/KR]; Life Science Biz 310, Pangyo-ro Seongnam-si, Gyeonggi-do 13494 (KR)
Inventors: AN, Kyungjun; (KR).
CHOI, Wooyoung; (KR).
HAM, Dongsoo; (KR).
KIM, Hun; (KR).
SHIN, Jinhwan; (KR).
HOPFER, Robert; (US).
KENSINGER, Richard, D.; (US).
KYAW, Moe; (US).
DESAUZIERS, Eric; (FR).
EL GUERCHE SEBLAIN, Clotilde; (FR).
TALAGA, Philippe; (FR)
Agent: DONALDSON, Timothy, B.; (US)
Priority Data:
62/371,529 05.08.2016 US
Title (EN) MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION
(FR) COMPOSITION D’UN CONJUGUÉ POLYSACCHARIDE-PROTÉINE PNEUMOCOCCIQUE MULTIVALENT
Abstract: front page image
(EN)Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 16 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 22F, 23F, and 33F, wherein two of the capsular polysaccharides are conjugated to tetanus toxoid and the remaining capsular polysaccharides are conjugated to CRM197, and wherein the two capsular polysaccharides that are conjugated to tetanus toxoid are selected from the group consisting of serotypes 1, 3, and 5. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.
(FR)L'invention concerne des compositions de conjugué pneumococcique multivalent à support mixte comprenant 16 différents conjugués polysaccharide-protéine capsulaire pneumococcique, chacun des conjugués comprenant un polysaccharide capsulaire provenant d'un sérotype différent de Streptococcus pneumoniae conjugué soit au toxoïde tétanique ou au CRM197, les sérotypes de Streptococcus pneumoniae étant choisis parmi 1, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 22F, 23F et 33F, deux des polysaccharides capsulaires étant conjugués au toxoïde tétanique et les polysaccharides capsulaires restants étant conjugués au CRM197, et les deux polysaccharides capsulaires qui sont conjugués à l'anatoxine tétanique étant choisis dans le groupe constitué par les sérotypes 1, 3 et 5. L'invention porte également sur des procédés de production du support mélangé, sur des compositions de conjugué pneumococcique multivalent et sur des procédés d'utilisation de ceux-ci pour la prophylaxie contre une infection à Streptococcus pneumoniae ou une maladie associée à la Streptococcus pneumoniae chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)