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1. (WO2018027024) COMPOSITIONS AND METHODS FOR STROKE PREVENTION IN PEDIATRIC SICKLE CELL ANEMIA PATIENTS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/027024    International Application No.:    PCT/US2017/045280
Publication Date: 08.02.2018 International Filing Date: 03.08.2017
IPC:
A61K 38/46 (2006.01), C12N 9/14 (2006.01), C12N 9/16 (2006.01), C12N 15/11 (2006.01), C12N 15/09 (2006.01)
Applicants: YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, Connecticut 06511 (US)
Inventors: BRADDOCK, Demetrios; (US)
Agent: DOYLE, Kathryn; (US).
LANDRY, Brian R.; (US).
SILVA, Domingos J.; (US).
SIMPSON, Mark D.; (US).
MANAS, Michael; (US).
DRISCOLL, Stephen J.; (US).
EDDE, Chantal; (US).
CROTTY, Justin; (US).
PLEHN-DUJOWICH, Debora; (US).
YOUNG, Jacque; (US)
Priority Data:
62/371,269 05.08.2016 US
Title (EN) COMPOSITIONS AND METHODS FOR STROKE PREVENTION IN PEDIATRIC SICKLE CELL ANEMIA PATIENTS
(FR) COMPOSITIONS ET MÉTHODES DE PRÉVENTION D'ACCIDENT VASCULAIRE CÉRÉBRAL CHEZ DES PATIENTS ATTEINTS DE DRÉPANOCYTOSE PÉDIATRIQUE
Abstract: front page image
(EN)The present invention includes compositions and methods for treating stroke in sickle cell anemia (SCA) patients. In certain embodiments, the patient is administered certain ENPP1- or ENNP3-containing polypeptides, mutants, or mutant fragments thereof.
(FR)La présente invention concerne des compositions et des méthodes de traitement de l'accident vasculaire cérébral chez des patients atteints de drépanocytose (SCA). Dans certains modes de réalisation, certains polypeptides contenant ENPP1 ou ENNP3, des mutants ou des fragments mutants de ceux-ci sont administrés au patient.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)