Search International and National Patent Collections

1. (WO2018026896) METHODS OF IDENTIFYING NOVEL PROTEINS AND ANTIGENS IN CANCER CELLS

Pub. No.:    WO/2018/026896    International Application No.:    PCT/US2017/045057
Publication Date: Fri Feb 09 00:59:59 CET 2018 International Filing Date: Thu Aug 03 01:59:59 CEST 2017
IPC: C12Q 1/68
G01N 33/53
Applicants: GEORGETOWN UNIVERSITY
Inventors: WELLSTEIN, Anton
Title: METHODS OF IDENTIFYING NOVEL PROTEINS AND ANTIGENS IN CANCER CELLS
Abstract:
The present invention provides methods of identifying neopeptides in abnormal cells, with the methods comprising sequencing long-read messenger RNA (mRNA) isolated from the abnormal cells, identifying splice variants that could be generated from the sequenced long-read mRNA, determining if the abnormal cells contain neopeptides that correlate with the identified splice variants. The methods may also comprise identifying at least one neoantigen on the neopeptides that are present in the abnormal cells.