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1. (WO2018026894) METHODS OF TREATMENT OF MYELODYSPLASTIC SYNDROME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026894    International Application No.:    PCT/US2017/045055
Publication Date: 08.02.2018 International Filing Date: 02.08.2017
IPC:
A61K 31/53 (2006.01), A61P 35/00 (2006.01)
Applicants: CELGENE CORPORATION [US/US]; 86 Morris Avenue Summit, NJ 07901 (US)
Inventors: AMATANGELO, Michael; (US).
HU, Xiaolan; (US).
THAKURTA, Anjan; (US)
Agent: RIEGER, Dale, L.; (US).
GEORGE, Nikilaos, C.; (US).
INSOGNA, Anthony, M.; (US).
BHUMRALKAR, Megha; (US).
BRUNER, Michael, J.; (US)
Priority Data:
62/429,649 02.12.2016 US
62/370,373 03.08.2016 US
Title (EN) METHODS OF TREATMENT OF MYELODYSPLASTIC SYNDROME
(FR) MÉTHODES DE TRAITEMENT DU SYNDROME MYÉLODYSPLASIQUE
Abstract: front page image
(EN)Provided are methods and compositions for treating a malignancy, particularly myeloplastic syndrome in patients carrying an IDH2 mutation by administering 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin- 4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol.
(FR)L'invention concerne des méthodes et des compositions permettant de traiter une malignité, en particulier le syndrome myéloplastique chez des patients porteurs d'une mutation IDH2 par administration de 2-méthyl-1-[(4- [6- (trifluorométhyl)pyridin-2-yl]-6-{[2- (trifluorométhyl)pyridin-4-yl] amino}-1,3,5-triazin-2-yl) amino]propan-2-ol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)