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1. (WO2018026816) PHOSPHOR-CONTAINING DRUG ACTIVATOR ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE, SYSTEM CONTAINING THE ACTIVATOR, AND METHODS FOR USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026816    International Application No.:    PCT/US2017/044901
Publication Date: 08.02.2018 International Filing Date: 01.08.2017
IPC:
A61N 5/10 (2006.01), A61N 5/06 (2006.01), A61K 41/00 (2006.01)
Applicants: IMMUNOLIGHT, LLC [US/US]; 1901 St. Antoine St. 6th Floor at Ford Field Detroit, MI 48226 (US).
DUKE UNIVERSITY [US/US]; 2020 West Main St. Suite 10 Durham, NC 27705 (US)
Inventors: WALDER, Harold; (US).
BOURKE, Frederic, A. Jr.; (US).
FATHI, Zakaryae; (US).
BEYER, Wayne; (US).
OLDHAM, Mark; (US).
ADAMSON, Justus; (US).
YOON, Paul; (US)
Agent: MASON, Derek J.; (US)
Priority Data:
62/369,482 01.08.2016 US
Title (EN) PHOSPHOR-CONTAINING DRUG ACTIVATOR ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE, SYSTEM CONTAINING THE ACTIVATOR, AND METHODS FOR USE
(FR) ACTIVATEUR DE MÉDICAMENT CONTENANT DU PHOSPHORE ACTIVÉ PAR UNE EXPOSITION AUX RAYONS X DÉRIVÉE DE MONTE CARLO.
Abstract: front page image
(EN)A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose distribution. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose comprising a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor.
(FR)Un activateur de médicament contenant du phosphore peut être activé à partir d'une exposition aux rayons X dérivés de Monte Carlo. L'activateur comprend un mélange, ou une suspension, d'un luminophore capable d'émettre de la lumière ultraviolette, et visible, lors de l'interaction avec les rayons X. La distribution des luminophores sur la cible est basée sur la distribution de dose de rayons X dérivée de Monte Carlo. Le traitement comprend l'activateur de médicament, un médicament photoactivable, un dispositif qui diffusent le médicament photoactivable et l'activateur comprenant un vecteur. Une source de rayons X produit la lumière ultraviolette et visible à l'intérieur du sujet, active le médicament photoactivable et provoque une réponse thérapeutique persistante. La dose comprend une séquence pulsée de rayons X distribuant de 0,5 à 2 Gy à la tumeur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)