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1. (WO2018026798) SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026798    International Application No.:    PCT/US2017/044871
Publication Date: 08.02.2018 International Filing Date: 01.08.2017
IPC:
C07D 471/10 (2006.01), C07D 487/10 (2006.01), A61K 31/407 (2006.01), A61K 31/438 (2006.01), A61P 25/00 (2006.01)
Applicants: APTINYX INC. [US/US]; 1801 Maple Avenue Suite 4300 Evanston, IL 60201 (US)
Inventors: KHAN, M., Amin; (US)
Agent: BRODOWSKI, Michael, H.; (US).
DAVENPORT, Andrew, M.; (US).
ASHRAF, Shovon; (US).
BUCHMAN, Joshua, J.; (US).
ARGENTIERI, Steven, R.; (US)
Priority Data:
62/443,915 09.01.2017 US
62/369,529 01.08.2016 US
Title (EN) SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME
(FR) MODULATEURS DE NMDA SPIRO-LACTAME ET LEURS PROCÉDÉS D'UTILISATION
Abstract: front page image
(EN)Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
(FR)L'invention concerne des composés ayant un potentiel dans la modulation de l'activité des récepteurs NMDA. De tels composés peuvent être utilisés dans le traitement d'états tels que la dépression et les troubles associés. L'invention concerne également des formulations administrées par voie orale et d'autres formes d'administration pharmaceutiquement acceptées des composés, y compris des formulations intraveineuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)