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1. (WO2018026538) NOVEL SCAFFOLDS FOR INTRACELLULAR COMPOUND DELIVERY FOR THE DETECTION OF CANCER CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026538    International Application No.:    PCT/US2017/043141
Publication Date: 08.02.2018 International Filing Date: 20.07.2017
IPC:
A61K 47/48 (2006.01), A61K 49/00 (2006.01), C07D 311/82 (2006.01)
Applicants: ISI LIFE SCIENCES INC. [US/US]; 610 Newport Center Newport Beach, California 92660 (US).
INDICATOR SYSTEMS INTERNATIONAL, INC [US/US]; 610 Newport Center Newport Beach, California 92660 (US).
SWISS, Gerald F. [US/US]; (US).
MORIARTY, Robert [US/US]; (US).
PARIZA, Richard [US/US]; (US).
WHITE, David [US/US]; (US).
FANTE, John [US/US]; (US).
HESSLER, III, Theordore [US/US]; (US).
KESHISHIAN, Craig [US/US]; (US)
Inventors: SWISS, Gerald F.; (US).
PARIZA, Richard; (US).
WHITE, David; (US).
FANTE, John; (US).
HESSLER, III, Theordore; (US).
KESHISHIAN, Craig; (US)
Agent: RAMOS, Robert, T.; (US)
Priority Data:
62/370,130 02.08.2016 US
62/378,128 22.08.2016 US
62/393,524 12.09.2016 US
PCT/US2017/013531 13.01.2017 US
15/595,930 15.05.2017 US
15/595,920 15.05.2017 US
Title (EN) NOVEL SCAFFOLDS FOR INTRACELLULAR COMPOUND DELIVERY FOR THE DETECTION OF CANCER CELLS
(FR) NOUVEAUX ÉCHAFAUDAGES POUR L'ADMINISTRATION INTRACELLULAIRE DE COMPOSÉS POUR LA DÉTECTION DE CELLULES CANCÉREUSES.
Abstract: front page image
(EN)Disclosed are folic acid or pteroic aicd conjugates and methods for using such conjugates. The conjugates described herein comprise a chemotherapeutic drug or imaging agent covalently bound thereto through a bond or via a linker that is intracellularly disrupted by, e.g., endogenous enzymes such as esterases, lipases and the like so as to provide for the chemotherapeutic drug free of the folic or pteroic acid.
(FR)L'invention porte sur des conjugués d'acide folique, ou d'acide ptéroïque, et sur des procédés d'utilisation de ces conjugués. Les conjugués de l'invention comprennent un médicament chimiothérapeutique, ou un agent d'imagerie lié de manière covalente à celui-ci par l'intermédiaire d'une liaison, ou par l'intermédiaire d'un liant qui est rompu dans la cellule par des enzymes endogènes telles que, par exemple , des estérases, des lipases et des enzymes similaires de manière à fournir un médicament chimiothérapeutique sans acide folique ou ptéroïque.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)