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1. (WO2018026449) IMPLANT SURFACES THAT ENHANCE OSTEOINDUCTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026449    International Application No.:    PCT/US2017/039989
Publication Date: 08.02.2018 International Filing Date: 29.06.2017
IPC:
A61F 2/30 (2006.01)
Applicants: TITAN SPINE, INC. [US/US]; 6140 W. Executive Drive Mequon, WI 53092 (US)
Inventors: GALLAGHER, Michelle B.; (US).
BERG, Mark E.; (US).
SCHNEIDER, Jennifer M.; (US)
Agent: CASEY, Kevin R.; (US).
ROSSI, Joseph, D.; (US).
SPLETZER, Christopher, M.; (US).
FORET, Philip, J.; (US).
LEGAARD, Paul, K.; (US)
Priority Data:
62/370,459 03.08.2016 US
Title (EN) IMPLANT SURFACES THAT ENHANCE OSTEOINDUCTION
(FR) SURFACES D'IMPLANT AMÉLIORANT L'OSTÉOINDUCTION
Abstract: front page image
(EN)Bone-contacting surfaces and free surfaces of orthopedic implants. The implants are additively manufactured, followed by mechanical, chemical, or mechanical and chemical erosion. At least some of the surfaces of the implants include an osteoinducting roughness that has micro-scale structures and nano-scale structures that facilitate and enhance osteoinduction and osteogenesis, as well as enhanced alkaline phosphatase, osterix, and osteocalcin expression levels along the pathway of mesenchymal stem cell differentiation to osteoblasts.
(FR)L'invention porte sur des surfaces de contact avec les os et sur des surfaces libres d'implants orthopédiques. Les implants sont fabriqués de manière additive, puis par érosion mécanique, chimique ou mécanique et chimique. Au moins certaines des surfaces des implants présentent une rugosité d'ostéoinduction qui comporte des structures à échelle microscopique et des structures à échelle nanométrique qui facilitent et améliorent l'ostéoinduction et l'ostéogenèse, ainsi que des niveaux d'expression améliorés de la phosphatase alcaline, de l'ostérix et de l'ostéocalcine le long de la voie de différenciation des cellules souches mésenchymateuses en ostéoblastes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)