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1. (WO2018026198) COMPOSITION FOR CARTILAGE REGENERATION AND PREPARATION METHOD THEREFOR
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Pub. No.: WO/2018/026198 International Application No.: PCT/KR2017/008353
Publication Date: 08.02.2018 International Filing Date: 02.08.2017
IPC:
A61L 27/36 (2006.01) ,C12N 5/077 (2010.01) ,A61K 35/32 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
077
Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
32
Bones; Tendons; Teeth; Cartilage
Applicants:
아주대학교산학협력단 AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 경기도 수원시 영통구 월드컵로 206 206, World cup-ro, Yeongtong-gu Suwon-si Gyeonggi-do 16499, KR
Inventors:
민병현 MIN, Byoung-Hyun; KR
박소라 PARK, So Ra; KR
최병현 CHOI, Byung Hyune; KR
김영직 KIM, Young Jick; KR
오현주 OH, Hyun Ju; KR
Agent:
이정현 LEE, Jeong Hyun; KR
Priority Data:
10-2016-009865802.08.2016KR
Title (EN) COMPOSITION FOR CARTILAGE REGENERATION AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION POUR LA RÉGÉNÉRATION DU CARTILAGE ET SON PROCÉDÉ DE PRÉPARATION
(KO) 연골 재생용 조성물 및 이의 제조방법
Abstract:
(EN) The present invention relates to a composition for cartilage regeneration, comprising fetal cartilage tissue-derived cells and a fetal cartilage tissue-derived extracellular matrix, and a preparation method thereof. A composition for cartilage regeneration according to the present invention can be used to fabricate a three-dimensional tissue having a size suitable for use as cartilage without an artificial scaffold, can easily be implanted regardless of the size and shape of a cartilage defect at an administration site thanks to ability to be administered in the form of gel as well as high the coatability and adhesiveness thereof, and exhibits high binding affinity for host tissues and has a phenotype of matured cartilage tissues, consequently showing the effect of being excellent in cartilage regeneration efficiency.
(FR) La présente invention concerne une composition pour la régénération du cartilage, comprenant des cellules dérivées des tissus cartilagineux fœtaux et une matrice extracellulaire dérivée des tissus cartilagineux fœtaux, et son procédé de préparation. Une composition pour la régénération du cartilage selon la présente invention peut être utilisée pour fabriquer un tissu tridimensionnel ayant une taille appropriée pour être utilisé comme cartilage sans échafaudage artificiel, peut être facilement implantée indépendamment de la taille et de la forme d'une anomalie du cartilage au niveau d'un site d'administration grâce à sa capacité à être administrée sous la forme d'un gel ainsi qu'à ses propriétés élevées d'aptitude au revêtement et d'adhésivité, et présente une affinité de liaison élevée pour les tissus hôtes et présente un phénotype de tissus cartilagineux matures, ayant ainsi comme effet de présenter une excellente efficacité de régénération du cartilage.
(KO) 본 발명은 태아연골조직 유래 세포 및 태아연골조직 유래 세포외기질을 포함하는 연골 재생용 조성물, 이의 제조방법에 관한 것이다. 본 발명에 따른 연골 재생용 조성물은 인공 지지체 없이 연골로 사용에 적합한 크기의 3차원 조직을 제작할 수 있으며, 조성물이 젤 형태로 투여 가능하면서도 높은 도포성과 부착성을 가지고 있기 때문에 투여 부위의 연골결손의 크기 및 모양에 관계없이 쉽게 이식이 가능하며, 숙주조직과의 높은 결합능을 보이면서 성숙한 연골조직의 표현형을 가짐으로써 연골재생 효능이 뛰어난 효과를 보인다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)