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1. (WO2018026190) BIOMARKER FOR PREDICTING CANCER PROGNOSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/026190    International Application No.:    PCT/KR2017/008336
Publication Date: 08.02.2018 International Filing Date: 02.08.2017
IPC:
C12Q 1/68 (2006.01), G01N 33/574 (2006.01), A61K 31/7088 (2006.01), A61K 39/395 (2006.01)
Applicants: NATIONAL CANCER CENTER [KR/KR]; (Madu-dong) 323, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408 (KR).
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street, Austin, Texas 78701 (US)
Inventors: LEE, Yeon Su; (KR).
KIM, In Hoo; (KR).
LEE, Yong Sun; (US).
LEE, Eun Kyung; (KR)
Agent: ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM; (Banpo-dong) 3rd Floor, 108, Sapyeong-daero, Seocho-gu, Seoul 06575 (KR)
Priority Data:
10-2016-0098635 02.08.2016 KR
Title (EN) BIOMARKER FOR PREDICTING CANCER PROGNOSIS
(FR) BIOMARQUEUR POUR PRÉDIRE UN PRONOSTIC D'UN CANCER
(KO) 암 예후 예측용 바이오마커
Abstract: front page image
(EN)The present invention relates to a genetic biomarker for predicting prognosis of cancer, particularly, thyroid cancer or liver cancer, a cancer prognosis predicting composition comprising an agent for measuring an expression level of the genetic biomarker, a cancer prognosis predicting kit comprising the composition, an information providing method for predicting prognosis of cancer by use of the kit, a system for screening a material prophylactic or curative of cancer by use of the genetic biomarker, and a pharmaceutical composition targeting the genetic biomarker to prevent or treat cancer. More particularly, the prognosis of a cancer patient can be predicted by measuring an expression level of the genetic biomarker of the present invention in the cancer patient, and the expression of a corresponding genetic biomarker responsible for poor prognosis can be suppressed, depending on prognosis prediction results, so that cancer patients can be more effectively treated.
(FR)La présente invention concerne un biomarqueur génétique pour prédire le pronostic d'un cancer, en particulier le cancer de la thyroïde ou le cancer du foie, une composition de prédiction de pronostic d'un cancer comprenant un agent pour mesurer un niveau d'expression du biomarqueur génétique, un kit de prédiction de pronostic d'un cancer comprenant la composition, un procédé d'obtention d'informations pour prédire le pronostic d'un cancer à l'aide du kit, un système de criblage d'un matériau prophylactique ou curatif d'un cancer à l'aide du biomarqueur génétique et une composition pharmaceutique ciblant le biomarqueur génétique pour prévenir ou traiter un cancer. Plus particulièrement, le pronostic d'un patient souffrant d'un cancer peut être prédit par mesure d'un niveau d'expression du biomarqueur génétique de la présente invention chez le patient souffrant d'un cancer et l'expression d'un biomarqueur génétique correspondant responsable d'un mauvais pronostic peut être supprimée, en fonction des résultats de prédiction de pronostic, de manière telle que les patients atteints d'un cancer peuvent être traités plus efficacement.
(KO)본 발명은 암, 특히 갑상선암 또는 간암의 예후를 예측하기 위한 유전자 바이오마커, 상기 유전자 바이오마커의 발현 수준을 측정하는 제제를 포함하는 암 예후 예측용 조성물, 상기 조성물을 포함하는 암 예후 예측용 키트, 상기 키트를 이용하여 암의 예후를 예측하기 위한 정보제공방법, 상기 유전자 바이오마커를 이용하여 암의 예방 또는 치료용 물질을 스크리닝하는 시스템 및 상기 유전자 바이오마커를 타겟으로 하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 보다 상세하게는 암 환자에서 본 발명의 유전자 바이오마커의 발현수준을 측정하여 암 환자의 예후를 예측할 수 있고, 예후 예측결과에 따라 암의 불량한 예후에 관여하는 해당 유전자 바이오마커의 발현을 억제할 수 있으므로, 암 환자를 보다 효과적으로 치료할 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)