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1. (WO2018026018) TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR

Pub. No.:    WO/2018/026018    International Application No.:    PCT/JP2017/028490
Publication Date: Fri Feb 09 00:59:59 CET 2018 International Filing Date: Sat Aug 05 01:59:59 CEST 2017
IPC: A61K 38/17
A61P 31/00
A61P 35/00
A61P 43/00
C07K 19/00
C12P 21/00
C12Q 1/02
Applicants: TOHOKU UNIVERSITY
国立大学法人東北大学
Inventors: OGASAWARA Koetsu
小笠原 康悦
Title: TREATMENT AND DIAGNOSIS OF CANCER OR INFECTIOUS DISEASE USING RECOGNITION MECHANISM OF T CELL RECEPTOR
Abstract:
Provided is a method for treating and diagnosing cancer or an infectious disease using the recognition mechanism of a T cell receptor. An NK cell function enhancer, said NK cell function enhancer comprising as an active ingredient a T cell receptor chimeric protein which is a fused protein consisting of a variable region of a T cell receptor capable of recognizing a cancer-specific antigen or a variable region of a T cell receptor capable of recognizing an antigen specific to a pathogen causative of an infectious disease and the Fc region of immunoglobulin, which binds to an MHC molecule complex of cancer cells to induce down modulation of MHC class 1 molecule complex and thus enables NK cells to recognize the cancer cells and kill the same; and an NK cell function enhancer which imparts to NK cells an ability to recognize cancer cells expressing an MHC class 1 molecule or infected cells infected with a pathogen causative of an infectious disease and thus enables the NK cells to kill the cancer cells or the infected cells by the T cell receptor chimeric protein-dependent cytotoxicity (TDCC) activity.