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1. (WO2018025242) METHODS FOR DIAGNOSING AND TREATING ESOPHAGEAL CANCER
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Pub. No.: WO/2018/025242 International Application No.: PCT/IB2017/054800
Publication Date: 08.02.2018 International Filing Date: 04.08.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
BAYLOR RESEARCH INSTITUTE [US/US]; 3310 Live Oak Street, Suite 501 Dallas, Texas 75204, US
Inventors:
GOEL, Ajay; US
MIYOSHI, Jinsei; US
Agent:
STELLMAN, Laurie B.F.; US
Priority Data:
62/371,02804.08.2016US
Title (EN) METHODS FOR DIAGNOSING AND TREATING ESOPHAGEAL CANCER
(FR) MÉTHODES DE DIAGNOSTIC ET DE TRAITEMENT DU CANCER DE L'ŒSOPHAGE
Abstract:
(EN) The current disclosure relates to therapeutic treatments and diagnostic methods for esophageal cancer based on the expression level of biomarker miRNAs. Aspects of the disclosure relate to a method of treating esophageal cancer (EC) in a patient, said method comprising: diagnosing the patient with esophageal cancer when the patient is determined to have an elevated or decreased level of expression of one or more miRNAs selected from mir- 15b, miR-17, mir-18a, mir-21, mir-23a, mir-24-2, mir-25, mir-27a, mir-93, mir-103, mir- 106b, mir-129-2, mir-139, mir-146b, mir-148a, mir-151, miR-155, mir-181a-1, mir-181a, mir-181b-1, mir-181b, mir-182, mir-183, mir-192, mir-194-1, mir-194-2, mir-196a-1, mir- 196a-2, mir-196b, mir-205, mir-215, mir-223, mir-224, mir-335, mir-338, mir-375, mir-421, mir-484, mir-505, mir-769, mir-944, mir-1468, mir-3648, and let-7i in a sample from a patient relative to the expression level of the one or more miRNAs in a control sample; and administering an effective amount of an esophageal treatment to the diagnosed patient.
(FR) La présente divulgation concerne des traitements thérapeutiques et des méthodes de diagnostic du cancer de l'œsophage basés sur le niveau d'expression de biomarqueurs de type miARN. Selon certains aspects, la présente divulgation concerne une méthode de traitement du cancer de l'œsophage (EC) chez un patient, ladite méthode comprenant : le diagnostic du cancer de l'œsophage chez le patient par détermination d'un niveau d'expression élevé ou réduit chez ledit patient d'un ou de plusieurs miARN choisis parmi miR-15b, miR-17, miR-18a, miR-21, miR-23a, miR-24-2, miR-25, miR-27a, miR-93, miR-103, miR-106b, miR-129-2, miR-139, miR-146b, miR-148a, miR-151, miR-155, miR-181a -1, miR-181a, miR-182, miR-183, miR-192, miR-194-1, miR-194-2, miR-196a -1, miR-196a-2, miR-196b, miR-205, miR-215, miR-223, miR-224, miR-335, miR-338, miR-375, miR-421, miR-484, miR-505, miR-769, miR-944, miR-1468, miR-3648, et let-7i dans un échantillon provenant du patient par rapport au niveau d'expression dudit ou desdits miARN dans un échantillon témoin; et l'administration d'une quantité efficace d'un traitement œsophagien au patient diagnostiqué.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)