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Pub. No.:    WO/2018/025044    International Application No.:    PCT/GB2017/052260
Publication Date: 08.02.2018 International Filing Date: 03.08.2017
A61K 39/39 (2006.01), A61K 9/50 (2006.01), A61K 9/51 (2006.01)
Applicants: THE UNIVERSITY OF BATH [GB/GB]; Claverton Down Bath Bath and North, East Somerset BA2 7AY (GB)
Inventors: SARTBAEVA, Asel; (GB).
WELLS, Stephen; (GB)
Agent: FINNIE, Isobel Lara; (GB)
Priority Data:
1613476.9 04.08.2016 GB
Abstract: front page image
(EN)The present invention provides a way to capture a biomolecule such as a protein in one or more layers of covalently bonded amorphous silica, forming a cage or shell which preserves the shape of the protein and prevents denaturation caused by heat and/or aging and/or non- physiological conditions, through unfolding and loss of secondary and/or higher order structure.
(FR)L'invention porte sur une manière de capturer une biomolécule, telle qu'une protéine, dans une ou plusieurs couches de silice amorphe liée de manière covalente, formant une enveloppe qui conserve la forme de la protéine et empêche la dénaturation provoquée par la chaleur, le vieillissement et/ou les conditions non physiologiques, par dépliage et perte de structure d'ordre secondaire et/ou supérieur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)