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1. (WO2018024905) CIRCULATING ESM-1 (ENDOCAN) IN THE ASSESSMENT OF ATRIAL FIBRILLATION AND STROKE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/024905    International Application No.:    PCT/EP2017/069864
Publication Date: 08.02.2018 International Filing Date: 04.08.2017
IPC:
G01N 33/68 (2006.01)
Applicants: ROCHE DIAGNOSTICS GMBH [DE/DE]; Sandhofer Straße 116 68305 Mannheim (DE) (DE only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
ROCHE DIAGNOSTICS OPERATIONS, INC. [US/US]; Business Area Roche Applied Science 9115 Hague Road Indianapolis, Indiana 46250 (US) (US only)
Inventors: KARL, Johann; (DE).
KASTNER, Peter; (DE).
LATINI, Roberto; (IT).
MASSON, Serge; (IT).
WIENHUES-THELEN, Ursula-Henrike; (DE).
ZIEGLER, André; (CH).
DIETRICH, Manuel; (DE).
SCHOTTEN, Uli; (DE).
ROLNY, Vinzent; (DE)
Agent: DICK, Alexander; Herzog Fiesser & Partner Patentanwälte PartG mbB Dudenstraße 46 68167 Mannheim (DE)
Priority Data:
16182825.6 04.08.2016 EP
Title (EN) CIRCULATING ESM-1 (ENDOCAN) IN THE ASSESSMENT OF ATRIAL FIBRILLATION AND STROKE
(FR) ESM-1 (ENDOCANE) CIRCULANT DANS L’ÉVALUATION DE LA FIBRILLATION AURICULAIRE ET DES ACCIDENTS VASCULAIRES CÉRÉBRAUX
Abstract: front page image
(EN)The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of ESM-1 in a sample from the subject, and comparing the amount of ESM-1 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure and/or at least one structural or functional abnormality of the heart associated with heart failure. Methods for predicting the risk of stroke are also disclosed, such as cardioembolic stroke and stroke associated with atrial fibrillation.
(FR)La présente invention concerne un procédé d’évaluation de la fibrillation auriculaire chez un sujet, ledit procédé comprenant les étapes de détermination de la quantité d’ESM-1 dans un échantillon provenant du sujet, et comparaison de la quantité d’ESM-1 à une quantité de référence, de façon à évaluer la fibrillation auriculaire. En outre, la présente invention concerne un procédé de diagnostic d’une insuffisance cardiaque et/ou au moins une anomalie structurale ou fonctionnelle du cœur associée à une insuffisance cardiaque. L’invention concerne en outre des procédés de prédiction du risque d’accident vasculaire cérébral, tel qu’un accident vasculaire cardio-embolique et un accident vasculaire cérébral associé à une fibrillation auriculaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)