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1. (WO2018024265) SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/024265    International Application No.:    PCT/CZ2017/050031
Publication Date: 08.02.2018 International Filing Date: 31.07.2017
IPC:
C07H 19/23 (2006.01), A61K 31/7064 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. [CZ/CZ]; Flemingovo namesti 542/2 16610 Praha 6 (CZ).
UNIVERZITA PALACKEHO V OLOMOUCI [CZ/CZ]; Krizkovskeho 511/8 771 47 Olomouc (CZ)
Inventors: HOCEK, Michal; (CZ).
TOKARENKO, Anna; (UA).
SMOLEN, Sabina; (PL).
HAJDUCH, Marian; (CZ).
DZUBAK, Petr; (CZ)
Agent: HARTVICHOVA, Katerina; (CZ)
Priority Data:
PV 2016-465 02.08.2016 CZ
Title (EN) SUBSTITUTED HETEROPENTADIENO-PYRROLOPYRIMIDINE RIBONUCLEOSIDES FOR THERAPEUTIC USE
(FR) RIBONUCLÉOSIDES HÉTÉROPENTADIÉNO-PYRROLOPYRIMIDINIQUES SUBSTITUÉS À USAGE THÉRAPEUTIQUE
Abstract: front page image
(EN)Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula (I), where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines in a wide variety of diseases including tumors of various histogenic origin.
(FR)Des ribonucléosides hétéropentadiéno-pyrrolopyrimidiniques substitués de formule générale (I), dans laquelle R est choisi dans le groupe comprenant le furan-2-yl, le furan-3-yle, le benzofuran-2-yle, le méthylsulfanyle, le méthoxy, l'amino, le diméthylamino, le méthyle ou le chloro, et un sel pharmaceutiquement acceptable de ceux-ci, leurs isomères optiques et des mélanges de ces isomères optiques. Les composés selon l'invention présentent de forts effets cytostatiques et cytotoxiques sur les lignées cellulaires dans une grande variété de maladies, y compris les tumeurs de différentes origines histogéniques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)