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1. (WO2018023980) METHOD FOR SYNTHESIZING PROTHIOCONAZOLE INTERMEDIATE 1-CHLORO-1-ACETYL CYCLOPROPANE

Pub. No.:    WO/2018/023980    International Application No.:    PCT/CN2017/077663
Publication Date: Fri Feb 09 00:59:59 CET 2018 International Filing Date: Thu Mar 23 00:59:59 CET 2017
IPC: C07C 45/67
C07C 49/327
Applicants: YANGZHOU TIANCHEN FINE CHEMICAL CO., LTD.
扬州天辰精细化工有限公司
Inventors: CHEN, Guoyun
陈国云
LUO, Zhibin
罗治斌
XIE, Jimin
谢吉民
WANG, Chen
王晨
LIU, Runxing
刘润兴
Title: METHOD FOR SYNTHESIZING PROTHIOCONAZOLE INTERMEDIATE 1-CHLORO-1-ACETYL CYCLOPROPANE
Abstract:
The present invention relates to the technical field of chemical engineering and production. Disclosed is a method for synthesizing 1-chloro-1-acetyl cyclopropane, a prothioconazole intermediate. The method comprises: mixing an acetyl ethanoate alkyl ester with a 1,2-dihalide alkane or disulfonated ethylene glycol to perform a monoalkylation reaction; after chlorination, mixing with a strong acid for hydrolysis to obtain 3,5-dichloropentan-2-one or 3-chloro-4-sulfonate pentan-2-one; and performing, by using a quaternary ammonium salt as a catalyst, a ring-closing reaction on the 3,5-dichloropentan-2-one or the 3-chloro-4-sulfonate pentan-2-one mixed with a basic solution to obtain the 1-chloro-1-acetyl cyclopropane. The invention reduces cost, lowers production of gas, liquid, and solid wastes, is safe and reliable, and has a high reaction yield.