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|1. (WO2018023980) METHOD FOR SYNTHESIZING PROTHIOCONAZOLE INTERMEDIATE 1-CHLORO-1-ACETYL CYCLOPROPANE|
|Applicants:||YANGZHOU TIANCHEN FINE CHEMICAL CO., LTD.
|Title:||METHOD FOR SYNTHESIZING PROTHIOCONAZOLE INTERMEDIATE 1-CHLORO-1-ACETYL CYCLOPROPANE|
The present invention relates to the technical field of chemical engineering and production. Disclosed is a method for synthesizing 1-chloro-1-acetyl cyclopropane, a prothioconazole intermediate. The method comprises: mixing an acetyl ethanoate alkyl ester with a 1,2-dihalide alkane or disulfonated ethylene glycol to perform a monoalkylation reaction; after chlorination, mixing with a strong acid for hydrolysis to obtain 3,5-dichloropentan-2-one or 3-chloro-4-sulfonate pentan-2-one; and performing, by using a quaternary ammonium salt as a catalyst, a ring-closing reaction on the 3,5-dichloropentan-2-one or the 3-chloro-4-sulfonate pentan-2-one mixed with a basic solution to obtain the 1-chloro-1-acetyl cyclopropane. The invention reduces cost, lowers production of gas, liquid, and solid wastes, is safe and reliable, and has a high reaction yield.