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1. (WO2018023130) TRIAZABUTADIENES AS CLEAVABLE CROSS-LINKERS

Pub. No.:    WO/2018/023130    International Application No.:    PCT/US2017/044737
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Tue Aug 01 01:59:59 CEST 2017
IPC: C07D 233/88
C07D 235/30
C07D 277/50
Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
Inventors: JEWETT, John C.
KIMANI, Flora W.
GUZMAN, Lindsay
CORNALI, Brandon M.
Title: TRIAZABUTADIENES AS CLEAVABLE CROSS-LINKERS
Abstract:
Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via click chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions.