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1. (WO2018023120) PRECISION THERAPEUTIC BIOMARKER SCREENING FOR CANCER

Pub. No.:    WO/2018/023120    International Application No.:    PCT/US2017/044712
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Tue Aug 01 01:59:59 CEST 2017
IPC: A61K 31/277
A61K 31/337
A61K 31/437
A61K 31/44
A61K 31/473
A61K 31/475
Applicants: UNIVERSITY OF MIAMI
Inventors: RAO, Jonnagadda, Sunil
LIU, Hongmei
Title: PRECISION THERAPEUTIC BIOMARKER SCREENING FOR CANCER
Abstract:
Computer-implemented processes for precision therapeutic biomarker screening for cancer include using a model-based overlapping clustering framework to assess large numbers of possible drugs and drug combinations against patient data, including cell line responsiveness. A multivariate regression model has been developed, along with a latent overlapping cluster indicator variable. The techniques employ a new finite mixture of multivariate regression (FMMR) model and expectation-maximization (EM) algorithm for modeling. The techniques can analyze large amounts of drug data and identify complex overlapping drug clusters, as well as cluster-wise drivers that facilitate identification of new drugs for treating pathologies, such as cancer, in patients.