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1. (WO2018023029) SMALL MOLECULE ACTIVATORS OF PARKIN ENZYME FUNCTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/023029    International Application No.:    PCT/US2017/044432
Publication Date: 01.02.2018 International Filing Date: 28.07.2017
IPC:
G01J 5/00 (2006.01), G01N 21/84 (2006.01)
Applicants: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH [US/US]; 200 First Street S.W. Rochester, Minnesota 55905 (US)
Inventors: SPRINGER, Wolfdieter; (US).
FIESEL, Fabienne C.; (US).
CAULFIELD, Thomas R.; (US)
Agent: CULHANE, Crystal L.; (US).
FOLLETT, Angela D.; (US).
FINN III, J. Patrick; (US)
Priority Data:
62/367,870 28.07.2016 US
Title (EN) SMALL MOLECULE ACTIVATORS OF PARKIN ENZYME FUNCTION
(FR) ACTIVATEURS DE PETITES MOLÉCULES DE LA FONCTION ENZYMATIQUE DE LA PARKINE
Abstract: front page image
(EN)The present disclosure relates to compounds for activating the enzymatic activity of an E3 ubiquitin ligase and methods for treating a disease or disorder in a subject with diminished E3 ubiquitin ligase enzymatic activity. In some embodiments, the present disclosure provides a compound of Formula (I) or a compound of Formula (II) or pharmaceutically acceptable salts thereof.
(FR)La présente invention concerne des composés permettant d'activer l'activité enzymatique d'une ubiquitine ligase E3 et des procédés de traitement d'une maladie ou d'un trouble chez un sujet présentant une activité enzymatique de l'ubiquitine ligase E3 diminuée. Dans certains modes de réalisation, la présente invention concerne un composé de formule I-formule (I) ou un composé de formule II. Formule (II) ou ses sels pharmaceutiquement acceptables.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)