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1. (WO2018023025) COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS ADN PD-1 INHIBITORS

Pub. No.:    WO/2018/023025    International Application No.:    PCT/US2017/044425
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Sat Jul 29 01:59:59 CEST 2017
IPC: C07K 14/725
A61K 39/00
A61K 39/395
A61K 35/17
C12N 5/0783
Applicants: NOVARTIS AG
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
ANAK, Oezlem
BILIC, Sanela
BROGDON, Jennifer
CAMERON, John, Scott
CHOU, William
HOWARD, Danny, Roland, Jr.
ISAACS, Randi
JUNE, Carl, H.
LACEY, Simon
MAUDE, Shannon
MELENHORST, Jan, J.
SHUSTER, Stephen
QUINTAS-CARDAMA, Alfonso
Inventors: ANAK, Oezlem
BILIC, Sanela
BROGDON, Jennifer
CAMERON, John, Scott
CHOU, William
HOWARD, Danny, Roland, Jr.
ISAACS, Randi
JUNE, Carl, H.
LACEY, Simon
MAUDE, Shannon
MELENHORST, Jan, J.
SHUSTER, Stephen
QUINTAS-CARDAMA, Alfonso
Title: COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS ADN PD-1 INHIBITORS
Abstract:
Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.