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1. WO2018022992 - CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

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Publication Number WO/2018/022992
Publication Date 01.02.2018
International Application No. PCT/US2017/044369
International Filing Date 28.07.2017
IPC
A61K 31/5377 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61K 2300/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2300Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K 31/122
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/235
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
235having an aromatic ring attached to a carboxyl group
A61K 31/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
Applicants
  • FLX BIO, INC. [US]/[US]
Inventors
  • BECK, Hilary, Plake
  • BIANNIC, Berenger
  • BUI, Minna Hue, Thanh
  • HU, Dennis, X.
  • KETCHAM, John, Michael
  • POWERS, Jay, Patrick
  • REILLY, Maureen, Kay
  • ROBLES-RESENDIZ, Omar
  • SHUNATONA, Hunter, Paul
  • WALKER, James, Ross
  • WUSTROW, David, Juergen
  • YOUNAI, Ashkaan
  • ZIBINSKY, Mikhail
  • JACKSON, Jeffrey James
Agents
  • YVON, Brigitte, L.
  • AZRIN, Linda, B.
  • AMENDT, Kevin, C.
  • BAUER, John, A.
  • ADAMS, Lisa
Priority Data
62/368,84829.07.2016US
62/426,08723.11.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF
(FR) MODULATEURS DE RÉCEPTEURS DE CHIMIOKINE ET LEURS UTILISATIONS
Abstract
(EN) Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.
(FR) La présente invention concerne, entre autres, des composés et des procédés d'utilisation de ceux-ci pour la modulation de l'activité de CCR4.
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