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1. (WO2018022978) CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES FOR TREATING BRONCHIECTASIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/022978    International Application No.:    PCT/US2017/044343
Publication Date: 01.02.2018 International Filing Date: 28.07.2017
IPC:
A61K 31/553 (2006.01), C07D 267/10 (2006.01), C07D 413/10 (2006.01), C07D 413/12 (2006.01)
Applicants: INSMED INCORPORATED [US/US]; 10 Finderne Ave. Building 10 Bridgewater, New Jersey 08807 (US).
ASTRAZENECA AB [SE/SE]; 151 85 Södertälje (SE).
FERNANDEZ, Carlos [US/US]; (US)
Inventors: FERNANDEZ, Carlos; (US).
HEYRMAN, Reinilde; (US).
SULLIVAN, Eugene; (US).
LONN, Hans Roland; (SE).
CONNOLLY, Stephen; (SE).
SWALLOW, Steven; (SE)
Agent: TUSCAN, Michael; (US).
DEO, Sandhya; (US).
VEITENHEIMER, Erich; (US)
Priority Data:
62/368,400 29.07.2016 US
Title (EN) CERTAIN (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES FOR TREATING BRONCHIECTASIS
(FR) CERTAINS (2S)-N-[(1S)-1-CYANO-2-PHÉNYLÉTHYL]-1,4-OXAZÉPANE-2-CARBOXAMIDES POUR LE TRAITEMENT DE LA BRONCHECTASIE.
Abstract: front page image
(EN)The present disclosure relates to methods for treating bronchiectasis, for example, non-cystic fibrosis bronchiectasis with compositions comprising an effective amount of certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds of Formula (I), including pharmaceutically acceptable salts thereof, that inhibit dipeptidyl peptidase 1 (DPP1) activity. Methods provided herein are useful for prophylaxis, increasing the lung function in a patient, and/or and/or decreasing the rate of pulmonary exacerbation in a patient. In one embodiment, the compound of Formula (I) is (2S)-N-{(1S)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide.
(FR)L'invention porte sur une méthode de traitement de la bronchectasie, par exemple la bronchectasie de fibrose non kystique avec des compositions comprenant certains (2S)-N-[(1S)-1-cyano-2-phényléthyl]-1,4-oxazépane-2-carboxamide de formule (I), y compris leurs sels, qui inhibent l'activité de la dipeptidyl peptidase 1 (DPP1). Les procédés de l'invention sont utiles pour la prophylaxie, l'augmentation de la fonction pulmonaire, et/ou la diminution du taux d'exacerbation pulmonaire chez un patient. Le composé de formule (I) est (2S)-N-{(1S)-1-cyano-2-[4-(3-méthyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl) phényl]éthyl}-1,4-oxazépane-2-carboxamide.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)