WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018022823) USES OF DOPAMINE BETA-HYDROXYLASE (DBH) INHIBITORS AND SEROTONIN RECEPTOR (5-HT) ANTAGONISTS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/022823    International Application No.:    PCT/US2017/044068
Publication Date: 01.02.2018 International Filing Date: 27.07.2017
IPC:
A61K 31/415 (2006.01), A61K 31/4164 (2006.01), A61K 31/417 (2006.01)
Applicants: ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD.; Offshore Incorporations Centre Coastal Building Wickhams Cay II Road Town Tortola, VG 1110 (VG).
PAN, Ke [CN/US]; (US) (MG only)
Inventors: PAN, Ke; (US).
LI, Qiang; (CN)
Agent: SHANAHAN, Carly, A.; (US).
BELISARIO, Martin, G.; (US).
BUTLER, Dennis, J.; (US).
BARANIAK, Andrew, P.; (US).
ELIAS, Ragi, A.i.; (US)
Priority Data:
62/367,728 28.07.2016 US
Title (EN) USES OF DOPAMINE BETA-HYDROXYLASE (DBH) INHIBITORS AND SEROTONIN RECEPTOR (5-HT) ANTAGONISTS FOR THE TREATMENT OF CANCER
(FR) UTILISATIONS D'INHIBITEURS DE LA DOPAMINE BÊTA-HYDROXYLASE (DBH) ET D'ANTAGONISTES DU RÉCEPTEUR DE LA SÉROTONINE (5-HT) POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Anti-cancer therapies involving non-cytotoxic dopamine beta-hydroxylase (DBH) inhibitors, such as nepicastat, etamicastat, and their analogs and pharmaceutically acceptable salts, and non-cytotoxic serotonin receptor antagonists, such as amperozide and its analogs and pharmaceutically acceptable salts are provided. The non-cytotoxic DBH inhibitors and serotonin receptor antagonists can be administered alone or in combination with one or more additional anti-cancer agents or anti-cancer therapies. Pharmaceutical compositions and combinations containing the non-cytotoxic DBH inhibitors and serotonin receptor antagonists and one or more additional anti-cancer agents, and methods of treating cancer using the pharmaceutical compositions and combinations are also provided.
(FR)L'invention concerne des traitements anticancéreux faisant intervenir des inhibiteurs non cytotoxiques de la dopamine bêta-hydroxylase (DBH), tels que le népicastat, l'étamicastat, et des analogues et sels pharmaceutiquement acceptables de ces derniers, et des antagonistes non cytotoxiques du récepteur de la sérotonine, tels que l'ampérozide et des analogues et sels pharmaceutiquement acceptables de ce dernier. Les inhibiteurs non cytotoxiques de la DBH et les antagonistes non cytotoxiques du récepteur de la sérotonine peuvent être administrés seuls ou en associations avec un ou plusieurs agents anticancéreux ou traitements anticancéreux supplémentaires. L'invention concerne également des compositions et combinaisons pharmaceutiques contenant les inhibiteurs non cytotoxiques de la DBH et les antagonistes non cytotoxiques du récepteur de la sérotonine ainsi qu'un ou plusieurs agents anticancéreux supplémentaires, et des méthodes de traitement du cancer utilisant les compositions et combinaisons pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)