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1. (WO2018022817) DONEPEZIL TRANSDERMAL DELIVERY SYSTEM
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/022817    International Application No.:    PCT/US2017/044050
Publication Date: 01.02.2018 International Filing Date: 26.07.2017
IPC:
A61K 31/445 (2006.01), A61K 9/70 (2006.01), A61P 25/28 (2006.01)
Applicants: CORIUM INTERNATIONAL, INC. [US/US]; 235 Constitution Drive Menlo Park, California 94025 (US)
Inventors: LEE, Eun Soo; (US).
JAIN, Amit K.; (US).
SINGH, Parminder; (US)
Agent: MOHR, Judy M.; (US).
SNOW, Claine L.; (US).
LI, Wen; (US).
MAHONEY, Jacqueline F.; (US)
Priority Data:
62/367,542 27.07.2016 US
62/367,502 27.07.2016 US
62/423,133 16.11.2016 US
62/444,745 10.01.2017 US
62/444,763 10.01.2017 US
62/457,794 10.02.2017 US
62/504,408 10.05.2017 US
62/504,391 10.05.2017 US
Title (EN) DONEPEZIL TRANSDERMAL DELIVERY SYSTEM
(FR) SYSTÈME D'ADMINISTRATION TRANSDERMIQUE DE DONÉPÉZIL
Abstract: front page image
(EN)A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises drug reservoir layer comprised of an acrylate copolymer, glycerine, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent that is bioequivalent to administration of the therapeutic agent orally.
(FR)L'invention concerne un système d'administration transdermique destiné à l'administration systémique de donépézil, le système comprenant une couche réservoir de médicament constituée d'un copolymère d'acrylate, de glycérine, et de la base du donépézil produite in situ par réaction du donépézil HCl et d'un sel alcalin. Le système est destiné au traitement de la maladie d'Alzheimer et permet une administration transdermique de l'agent thérapeutique qui est bioéquivalente à l'administration de l'agent thérapeutique par voie orale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)