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1. (WO2018022548) METHODS TO GENERATE POLYMER SCAFFOLDS HAVING A GRADIENT OF CROSSLINKING DENSITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/022548 International Application No.: PCT/US2017/043601
Publication Date: 01.02.2018 International Filing Date: 25.07.2017
IPC:
C12N 5/00 (2006.01)
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL[US/US]; 109 Church St. Chapel Hill, North Carolina 27516, US
Inventors: ALLBRITTON, Nancy; US
WANG, Yuli; US
GUNASEKARA, Hennayaka Mudiyanselage Dulan; US
SIMS, Christopher; US
Agent: BONNEN, Alice M.; US
Priority Data:
62/367,33927.07.2016US
Title (EN) METHODS TO GENERATE POLYMER SCAFFOLDS HAVING A GRADIENT OF CROSSLINKING DENSITY
(FR) PROCÉDÉS POUR GÉNÉRER DES ÉCHAFAUDAGES POLYMÈRES AYANT UN GRADIENT DE DENSITÉ DE RÉTICULATION
Abstract: front page image
(EN) The present invention is directed to a method of making a live cell construct or a support, comprising: (a) providing a non-cellular organic polymer support having a top surface, a bottom surface, and an intermediate portion there between, and (b) contacting a cross-linking agent to one surface of said support for a time sufficient to generate a gradient of cross-linking of said polymer in said intermediate portion. Also provided are live cell constructs, supports, and methods of use of the supports and live cell constructs.
(FR) La présente invention concerne un procédé de fabrication d'une construction de cellules vivantes ou d'un support, consistant : (a) à fournir un support polymère organique non cellulaire ayant une surface supérieure, une surface inférieure et une partie intermédiaire entre celles-ci, et (b) à mettre en contact un agent de réticulation avec une surface dudit support pendant une durée suffisante pour générer un gradient de réticulation dudit polymère dans ladite partie intermédiaire. L'invention concerne également des constructions de cellules vivantes, des supports et des procédés d'utilisation des supports et des constructions de cellules vivantes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)