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1. (WO2018022479) ANTI-HSPA5 (GRP78) ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/022479    International Application No.:    PCT/US2017/043448
Publication Date: 01.02.2018 International Filing Date: 24.07.2017
IPC:
C07K 16/18 (2006.01), A61K 39/00 (2006.01)
Applicants: BIOGEN MA INC. [US/US]; 225 Binney Street Cambridge, Massachusetts 02142 (US).
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; 1800 Grant Street 8th Floor Denver, Colorado 80203 (US)
Inventors: BENNETT, Jeffrey L.; (US).
RANSOHOFF, Richard M.; (US).
SHIMIZU, Fumitaka; (JP).
SCHALLER, Kristin L.; (US)
Agent: KOIPALLY, Joseph J.; (US).
BRENNAN, Jack; (US)
Priority Data:
62/366,452 25.07.2016 US
62/502,188 05.05.2017 US
Title (EN) ANTI-HSPA5 (GRP78) ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-HSPA5 (GRP78) ET LEURS UTILISATIONS
Abstract: front page image
(EN)This disclosure provides anti-HSPA5 antibodies. Also featured is a method for delivering an agent into the brain, spinal cord, or other component of the central nervous system. In addition, methods of identifying a human subject at risk of relapse of neuromyelitis optica (NMO) or neuropsychiatric systemic lupus erythematosus (NP-SLE) are disclosed, as are methods of determining the severity of an attack of NMO or NP-SLE, and methods of diagnosing NP-SLE.
(FR)L'invention concerne des anticorps anti-HSPA5. L'invention concerne également un procédé d'administration d'un agent dans le cerveau, la moelle épinière ou un autre composant du système nerveux central. De plus, l'invention concerne des procédés d'identification d'un sujet humain présentant un risque de rechute de la neuromyélite optique (NMO) ou du lupus érythémateux systémique neuropsychiatrique (NP-SLE), ainsi que des procédés de détermination de la gravité d'une attaque de NMO ou de NP-SLE, et des procédés de diagnostic de NP-SLE.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)