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1. (WO2018022125) RADIOACTIVE PHOSPHOLIPID METAL CHELATES FOR CANCER IMAGING AND THERAPY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/022125 International Application No.: PCT/US2016/060495
Publication Date: 01.02.2018 International Filing Date: 04.11.2016
IPC:
A61K 51/04 (2006.01) ,A61P 35/00 (2006.01) ,G01N 33/574 (2006.01) ,G01N 33/60 (2006.01) ,C07B 59/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58
involving labelled substances
60
involving radioactive labelled substances
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION[US/US]; 614 Walnut Street Madison, Wisconsin 53726, US
Inventors: WEICHERT, Jamey; US
PINCHUK, Anatoly; US
HERNANDEZ, Reinier; US
Agent: HEIDMANN, Keith; US
Priority Data:
62/366,34425.07.2016US
Title (EN) RADIOACTIVE PHOSPHOLIPID METAL CHELATES FOR CANCER IMAGING AND THERAPY
(FR) CHÉLATES MÉTALLIQUES DE PHOSPHOLIPIDES RADIOACTIFS POUR L'IMAGERIE ET LA THÉRAPIE CONTRE LE CANCER.
Abstract:
(EN) Alkylphosphocholine analogs incorporating a chelating moiety that chelates a radioactive metal isotope are disclosed herein. The alkylphophocholine analogs, which can be used to treat or detect solid tumors, have the formula: [Formula should be inserted here]. R1 includes a chelating agent that is chelated to a metal atom, wherein the metal atom is a positron or single photon emitting metal isotope with a half life of greater than or equal to 4 hours, or an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is -H, -OH, -COOH, -COOX, -OCOX, or -OX, wherein X is an alkyl or an arylalkyl; R2 is -N+H3, -N+H2Z, -N+HZ2, or -N+Z3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2.
(FR) L'invention porte sur des analogues d'Alkylphosphocholine incorporant un fragment de chélation d'un isotope de métal radioactif. Les analogues d'alkylphophocholine, qui peuvent être utilisés pour traiter ou détecter des tumeurs solides, ont la formule : [formule devrait être insérée ici]. R1 comprend un agent de chélation qui est chélaté en atome métallique. L'atome de métal est un isotope de métal émetteur de positrons, ou de photon, unique a une demi-vie supérieure ou égale à 4 heures, ou un isotope alpha, beta ou Auger émettant un isotope métallique ayant une demi-vie supérieure à 6 heures et inférieure à 30 jours. a est 0 ou 1; n est un nombre entier de 12 à 30; m est 0 ou 1; Y est-H,-OH,-COOH,-COOX,-OCOX, ou-OX, où X est un alkyle ou un arylalkyle; R2 est-n + H 3,-n + H 2 Z,-n + HZ 2, ou-n + Z 3, dans laquelle chaque Z représente indépendamment un alkyle ou un aroalkyle; et b représente 1 ou 2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)