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1. (WO2018021977) GLYCINE METABOLISM MODULATORS AND USES THEREOF

Pub. No.:    WO/2018/021977    International Application No.:    PCT/SG2017/050389
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Tue Aug 01 01:59:59 CEST 2017
IPC: C07D 239/94
C07D 401/14
C07D 403/12
C07D 413/12
C07D 471/04
C07D 471/06
A61K 31/517
A61P 3/00
A61P 25/00
A61P 25/28
A61P 29/00
A61P 35/00
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: NACRO, Kassoum
Title: GLYCINE METABOLISM MODULATORS AND USES THEREOF
Abstract:
The present invention relates to a compound of general formula (I) and/or its solvates, hydrates and pharmaceutically acceptable salts, which are modulators of glycine metabolism. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with glycine metabolism or a pathway where glycine decarboxylase (GLDC, or glycine cleavage system) plays a role. In a preferred embodiment the disorders/conditions/disease is cancer, inflammatory conditions, Alzheimer's disease, metabolic disorders and CNS disorders.