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|1. (WO2018021977) GLYCINE METABOLISM MODULATORS AND USES THEREOF|
|Applicants:||AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
|Title:||GLYCINE METABOLISM MODULATORS AND USES THEREOF|
The present invention relates to a compound of general formula (I) and/or its solvates, hydrates and pharmaceutically acceptable salts, which are modulators of glycine metabolism. The present invention also relates to the methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with glycine metabolism or a pathway where glycine decarboxylase (GLDC, or glycine cleavage system) plays a role. In a preferred embodiment the disorders/conditions/disease is cancer, inflammatory conditions, Alzheimer's disease, metabolic disorders and CNS disorders.