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1. (WO2018021846) MICROJET DRUG DELIVERY SYSTEM HAVING IMPROVED SKIN PENETRATION PERFORMANCE OF DRUG THROUGH FRACTIONAL LASER SKIN PRE-ABLATION

Pub. No.:    WO/2018/021846    International Application No.:    PCT/KR2017/008102
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Fri Jul 28 01:59:59 CEST 2017
IPC: A61M 5/30
A61M 5/42
A61M 5/20
H01S 3/16
G02B 27/14
Applicants: SNU R&DB FOUNDATION
서울대학교 산학협력단
Inventors: YOH, Jai-Ick
여재익
JANG, Hun Jae
장헌재
Title: MICROJET DRUG DELIVERY SYSTEM HAVING IMPROVED SKIN PENETRATION PERFORMANCE OF DRUG THROUGH FRACTIONAL LASER SKIN PRE-ABLATION
Abstract:
The present invention relates to a drug delivery system for effectively administering a drug into human (or animal) body tissue. The microjet drug delivery system provided by the present invention comprises: (a) a microjet injector comprising: a pressure chamber sealed at a part of a side surface thereof by an elastic membrane and hermetically filled with a pressure generating liquid; and a drug chamber disposed adjacent to the pressure chamber with the elastic membrane therebetween, containing a drug solution therein, and having a micro-nozzle formed at one side thereof, the micro-nozzle being provided to discharge the drug solution to the outside therethrough; (b) a laser generator, configured to generate a laser beam and emit the laser beam to the outside, for irradiating a laser beam onto the pressure generating liquid in the microjet injector to generate bubbles; and (c) a fractional laser filter module for dividing the beam incident from the laser generator into a plurality of fractional laser beams, each reduced in diameter, and for outputting the fractional laser beams. The microjet drug delivery system of the present invention as described above selectively removes the stratum corneum through a process of pre-ablating skin in advance using a fractional laser beam, and performs drug microjet injection at a site which is relatively weakened due to the removal of the stratum corneum, thereby effectively infiltrating a drug into skin tissue.