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1. (WO2018021826) NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT
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Pub. No.: WO/2018/021826 International Application No.: PCT/KR2017/008052
Publication Date: 01.02.2018 International Filing Date: 26.07.2017
IPC:
C07D 403/12 (2006.01) ,C07D 403/10 (2006.01) ,C07D 413/12 (2006.01) ,C07D 413/10 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/53 (2006.01) ,A61K 31/5395 (2006.01) ,A23L 33/10 (2016.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5395
having two or more nitrogen atoms in the same ring, e.g. oxadiazines
[IPC code unknown for A23L 33/10]
Applicants:
한국화학연구원 KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY [KR/KR]; 대전시 유성구 가정로 141 141, Gajeong-ro Yuseong-gu Daejeon 34114, KR
국립암센터 NATIONAL CANCER CENTER [KR/KR]; 경기도 고양시 일산동구 일산로 323 323, Ilsan-ro, Ilsandong-gu Goyang-si Gyeonggi-do 10408, KR
Inventors:
윤창수 YUN, Chang Soo; KR
김형래 KIM, Hyoung Rae; KR
김필호 KIM, Pilho; KR
박지훈 PARK, Chi Hoon; KR
안선주 AHN, Sunjoo; KR
이정옥 LEE, Chong Ock; KR
정희정 JUNG, Hee Jung; KR
조성윤 CHO, Sung Yun; KR
하재두 HA, Jae Du; KR
황종연 HWANG, Jong Yeon; KR
박종배 PARK, Jong Bae; KR
이승훈 LEE, Seung-Hoon; KR
Agent:
이원희 LEE, Won Hee; KR
Priority Data:
10-2016-009456026.07.2016KR
Title (EN) NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT
(FR) NOUVEAU DÉRIVÉ DE PYRIMIDINE-2,4-DIAMINE ET COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER CONTENANT CELUI-CI COMME INGRÉDIENT ACTIF
(KO) 신규한 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물
Abstract:
(EN) The present invention relates to a novel pyrimidine-2,4-diamine derivative or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for the prevention or treatment of cancer containing the same as an active ingredient. The compound according to the present invention has an excellent effect of inhibiting the activity of an inverse-forming lymphoma kinase (ALK), thereby improving a therapeutic effect on cancer cells having an inverse-forming lymphoma kinase (ALK) fusion protein such as EML4-ALK or NPM-ALK, and the present invention is expected to be effective in preventing the recurrence of cancer, and thus can be usefully used as a pharmaceutical composition for preventing or treating cancer.
(FR) La présente invention concerne un dérivé de pyrimidine-2,4-diamine ou son sel pharmaceutiquement acceptable et une composition pharmaceutique pour la prévention ou le traitement du cancer contenant celui-ci en tant que ingrédient actif. Le composé selon la présente invention a un excellent effet d'inhibition de l'activité d'une kinase de lymphome à formation inverse (ALK), ce qui permet d'améliorer un effet thérapeutique sur des cellules cancéreuses présentant une kinase de lymphome à formation inverse (ALK) protéine de fusion telle que EML4-ALK ou NPM-ALK, et la présente invention devrait être efficace pour prévenir la récurrence du cancer, et peut donc être utilisé de manière utile en tant que composition pharmaceutique pour prévenir ou traiter le cancer.
(KO) 본 발명은 신규한 피리미딘-2,4-디아민 유도체 또는 이의 약학적으로 허용 가능한 염 및 이를 유효성분으로 함유하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명에 의한 화합물은 역형성 림프종 키나아제(ALK) 활성을 억제하는 효과가 우수하므로 이에 따른 EML4-ALK, NPM-ALK 등의 역형성 림프종 키나아제(ALK) 융합 단백질을 가진 암세포에 대한 치료효과가 향상될 수 있으며, 암의 재발을 막는데 효과적일 것으로 예상되므로 암의 예방 또는 치료용 약학적 조성물로 유용하게 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)