The present invention relates to an endomicroscopic coupling module coupled to a microscope such that a biological sample can be observed through the microscope. The endomicroscopic coupling module according to one embodiment of the present invention comprises: an optical path changing adapter coupled to an object lens unit of the microscope and changes the path of observation light; and a probe mount positioned at one side of the optical path changing adapter and comprising an endoscopic probe of which at least one part is inserted into a biological sample. The optical path changing adapter comprises an adjustment unit for adjusting the angle of the endoscopic probe with respect to the ground surface by rotating the probe mount. According to the present invention, provided is an endomicroscopic coupling module, which is easily attachable/detachable to/from various types of optical microscopes possessed by many biomedical labs and biopsy labs.