WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2018021518) SOLID PREPARATION HAVING IMPROVED LIGHT STABILITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/021518    International Application No.:    PCT/JP2017/027391
Publication Date: 01.02.2018 International Filing Date: 28.07.2017
IPC:
A61K 31/485 (2006.01), A61K 9/14 (2006.01), A61K 9/16 (2006.01), A61K 9/20 (2006.01), A61K 9/48 (2006.01), A61K 47/02 (2006.01), A61K 47/08 (2006.01), A61K 47/10 (2006.01), A61K 47/22 (2006.01), A61K 47/26 (2006.01), A61P 17/04 (2006.01)
Applicants: TORAY INDUSTRIES, INC. [JP/JP]; 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666 (JP)
Inventors: TAKAKI, Suguru; (JP).
MINAKAMI, Satoshi; (JP).
OHTA, Kotoe; (JP)
Priority Data:
2016-150238 29.07.2016 JP
Title (EN) SOLID PREPARATION HAVING IMPROVED LIGHT STABILITY
(FR) PRÉPARATION SOLIDE AYANT UNE MEILLEURE STABILITÉ À LA LUMIÈRE.
(JA) 光安定性の向上した固形製剤
Abstract: front page image
(EN)The purpose of the present invention is to provide a solid preparation which contains a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and which is stable against light without requiring a light-shielding coating. Provided by the present invention is a solid preparation that contains an active ingredient comprising a 4,5-epoxymorphinan derivative represented by formula (II) or a pharmacologically acceptable acid addition salt thereof, and at least one type of stabilizing agent selected from the group consisting of n-propyl gallate, sodium bisulfite, dibutylhydroxytoluene, butylated hydroxyanisole, tocopherol, and D-isoascorbic acid, wherein: the weight of the active ingredient accounts for 0.00001-0.01 wt% of the weight of the solid preparation; and the weight of the stabilizing agent accounts for 0.005-5 wt% of the weight of the solid preparation.
(FR)Le but de la présente invention est de fournir une préparation solide qui contient un dérivé de 4,5-époxymorphinane, ou un sel d'addition d'acide comparable, qui est stable et ne nécessite pas de revêtement de protection contre la lumière. La préparation solide contient un ingrédient actif comprenant un dérivé de 4,5-époxymorphinane représenté par la formule (II), ou un sel d'addition acide comparable, et au moins un agent stabilisant parmi le gallate de n-propyle, le bisulfite de sodium, le dibutylhydroxytoluène, l'hydroxyanisole butylé, le tocophérol et l'acide D-isoascorbique, où le poids de l'ingrédient actif représente de 0,00001 à 0,01 % de la préparation solide, et le poids de l'agent stabilisant représente 0 005 à 5 % de la préparation solide.
(JA)本発明は遮光性コーティングを行わなくても光に対して安定な、4,5-エポキシモルヒナン誘導体又はその薬理学的に許容される酸付加塩を含有する固形製剤を提供することを目的としている。本発明は、以下に代表される4,5-エポキシモルヒナン誘導体又はその薬理学的に許容される酸付加塩からなる有効成分と、没食子酸n-プロピル、亜硫酸水素ナトリウム、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、トコフェロール及びD-イソアスコルビン酸からなる群から選択される1種以上の安定化剤と、を含有し、上記有効成分の重量は、固形製剤の重量あたり0.00001~0.01重量%であり、上記安定化剤の重量は、固形製剤の重量あたり0.005~5重量%である、固形製剤を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)