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1. (WO2018020477) METHODS AND COMPOSITIONS FOR TREATING HYPERTRIGLYCERIDEMIA

Pub. No.:    WO/2018/020477    International Application No.:    PCT/IB2017/054618
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Sat Jul 29 01:59:59 CEST 2017
IPC: A61K 31/557
A61K 45/06
A61K 49/14
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
GUNMA UNIVERSITY
MIYASHITA, Kazuya
Inventors: MIYASHITA, Kazuya
YOUNG, Stephen G.
BEIGNEUX, Anne P.
FONG, Loren G.
NAKAJIMA, Katsuyuki
Title: METHODS AND COMPOSITIONS FOR TREATING HYPERTRIGLYCERIDEMIA
Abstract:
The current disclosure relates to a novel therapeutic strategy for patients with hypertriglyceridemia and/or chylomicronemia, wherein the patient is determined to have autoantibodies to GPIHBP1. It was unexpectedly found that autoantibodies to GPIHBP1, a GPI anchored protein of capillary endothelial cells that shuttles lipoprotein lipase to its site of action in the capillary lumen, were found to be present in patients with hypertriglyceridemia, and that the autoantibodies blocked the binding of lipoprotein lipase (LPL) to GPIHBP1. Accordingly, aspects of the disclosure relate to a method for treating hypertriglyceridemia and/or chylomicronemia in a patient comprising administering a therapeutically effective amount of an immunosuppressive treatment and/or GPIHBP1 activator to the patient; wherein the patient has been determined to have GPIHBP1 autoantibodies.