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1. (WO2018020474) SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/020474    International Application No.:    PCT/IB2017/054612
Publication Date: 01.02.2018 International Filing Date: 28.07.2017
IPC:
C07D 513/04 (2006.01), A61K 31/429 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01), A61P 17/00 (2006.01), A61P 19/00 (2006.01)
Applicants: LUPIN LIMITED [IN/IN]; Kalpataru Inspire, 3rd Floor, Off Western Express Highway, Santacruz (East) Maharashtra Mumbai 400 055 (IN)
Inventors: KUKREJA, Gagan; (IN).
IRLAPATI, Nageswara, Rao; (IN).
JAGDALE, Arun, Rangnath; (IN).
DESHMUKH, Gokul, Keruji; (IN).
VYAVAHARE, Vinod, Popatrao; (IN).
KULKARNI, Kiran, Chandrashekhar; (IN).
SINHA, Neelima; (IN).
PALLE, Venkata, P.; (IN).
KAMBOJ, Rajender, Kumar; (IN)
Agent: MAJUMDAR, Subhatosh; (IN).
GANGULI, Dr., Sanchita; (IN).
SEN, Abhishek; (IN).
VENKATESH, Mythili; (IN).
MAJUMDAR, Amrita; (IN).
KUNDU, Subarna; (IN).
CHAUBEY, Priyanka; (IN)
Priority Data:
201621026107 29.07.2016 IN
Title (EN) SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS
(FR) COMPOSÉS DE THIAZOLO-PYRIDINE SUBSTITUÉS EN TANT QU'INHIBITEURS DE MALT1
Abstract: front page image
(EN)Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disclosed are pharmaceutical compositions containing a compound of the invention and a method of treating a patient for an autoimmune or an inflammatory disease or disorder, for example, a cancer, by administering a compound of the invention.
(FR)L'invention concerne des composés de formule générale (I), dans laquelle R1 à R3 sont tels que définis dans la description, et sont destinés à être utilisés en tant qu'inhibiteurs de MALT1 dans le traitement de maladies ou de troubles auto-immuns et inflammatoires. Des procédés de synthèse des composés sont également décrits. L'invention porte également sur des compositions pharmaceutiques contenant un composé de l'invention et sur un procédé de traitement d'un patient pour une maladie ou un trouble auto-immun ou inflammatoire, par exemple, un cancer, par administration d'un composé de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)