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1. (WO2018020326) MONOSIALOGANGLIOSIDE-BASED NEUROPROTECTIVE AGENT OBTAINED FROM PORCINE BRAIN

Pub. No.:    WO/2018/020326    International Application No.:    PCT/IB2017/001232
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Wed Jul 26 01:59:59 CEST 2017
IPC: C07H 15/10
C07H 1/08
Applicants: LONG SHENG PHARMA LIMITED
ЛОНГ ШЕНГ ФАРМА ЛИМИТЕД
Inventors: MANDROVSKIY, Valeriy Alexeevich
МАНДРОВСКИЙ, Валерий Алексеевич
Title: MONOSIALOGANGLIOSIDE-BASED NEUROPROTECTIVE AGENT OBTAINED FROM PORCINE BRAIN
Abstract:
Method for isolating monosialotetrahexosylganglioside (GMl) involves preparing porcine brain extract, adding sodium hydroxide, separating, conducting adsorption and desorption of extract, stirring, transferring mixture, adding hydrochloric acid, separating, washing, drying, performing chromatographic separation, collecting fraction, concentrating, dissolving in e.g. trichloromethane, passing through resin column, concentrating, adding acetone, filtering, drying, diluting, adding activated carbon, stirring, re- filtering, concentrating, adding acetone, cooling and drying.