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1. (WO2018019867) N-ACETYL HOMOSERINE
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Pub. No.: WO/2018/019867 International Application No.: PCT/EP2017/068841
Publication Date: 01.02.2018 International Filing Date: 26.07.2017
IPC:
C07C 233/47 (2006.01) ,C12P 13/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
45
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
46
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
47
having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
04
Alpha- or beta-amino acids
06
Alanine; Leucine; Isoleucine; Serine; Homoserine
Applicants: EVONIK DEGUSSA GMBH[DE/DE]; Rellinghauser Straße 1-11 45128 Essen, DE
Inventors: HAAS, Thomas; DE
SCHAFFER, Steffen; DE
BÜLTER, Thomas; DE
BECK, Simon; DE
Priority Data:
16181431.427.07.2016EP
Title (EN) N-ACETYL HOMOSERINE
(FR) N-ACÉTYL HOMOSÉRINE
Abstract:
(EN) The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cell in an aqueous medium with acetate wherein the recombinant cell comprises an increased activity relative to a wild type cell of (a) an enzyme E1,a homoserine dehydrogenase (EC1.1.1.3) and/or an enzyme E5, an aspartokinase (EC2.7.2.4); and (b) an enzyme E2, a homoserine O-acetyl transferase (EC2.3.1.31) and the acetate is maintained at a concentration of at least about 0.001 g/L in the aqueous medium.
(FR) La présente invention concerne un composé de formule générale (I). La présente invention concerne également un procédé de production de N-acétyl homosérine et/ou des dérivés de celui-ci, le procédé comprenant la mise en contact d'au moins une cellule recombinante dans un milieu aqueux avec de l'acétate, où la cellule recombinante comprenant une activité accrue par rapport à une cellule de type sauvage de (a) une enzyme E 1 , une homosérine déshydrogénase (EC1.1.1.3) et/ou une enzyme E 5 , une aspartokinase (EC2.7.2.4); et (b) une enzyme E 2 , une homosérine O-acétyl transférase (EC2.3.1.31) et l'acétate est maintenu à une concentration d'au moins environ 0,001 g/L dans le milieu aqueux.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)