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1. (WO2018019748) 5'S-LNA NUCLEOTIDES AND OLIGONUCLEOTIDES

Pub. No.:    WO/2018/019748    International Application No.:    PCT/EP2017/068575
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Tue Jul 25 01:59:59 CEST 2017
IPC: C07H 19/06
C07H 19/16
C07H 21/00
C07H 1/00
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: BLEICHER, Konrad
DUSCHMALÉ, Joerg
SAHA, Goutam
SHAIKH, Juber Abdulhamid
Title: 5'S-LNA NUCLEOTIDES AND OLIGONUCLEOTIDES
Abstract:
The invention relates to a compound of formula (I) wherein R2 and R4 are joined and together form a group, such a -CH2O-. The compound of formula (I) can be used in the manufacture of 5'S-LNA oligonucleotides as antisense drugs.