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1. (WO2018019301) FLUORINE-SUBSTITUTED TRIPTOLIDE DERIVATIVE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/019301    International Application No.:    PCT/CN2017/094991
Publication Date: 01.02.2018 International Filing Date: 28.07.2017
IPC:
C07J 73/00 (2006.01), A61K 31/57 (2006.01), A61P 35/00 (2006.01), A61P 37/06 (2006.01)
Applicants: CINKATE PHARMACEUTICAL INTERMEDIATES CO., LTD. [CN/CN]; Building 3, No.67 Libing Road Zhangjiang Inno Park, Pudong New Area Shanghai 201203 (CN)
Inventors: ZHANG, Peng; (CN).
BAO, Lixia; (CN).
LIU, Xiangchao; (CN).
HE, Lijun; (CN).
XIAO, Fei; (CN)
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333 (CN)
Priority Data:
201610617459.5 29.07.2016 CN
Title (EN) FLUORINE-SUBSTITUTED TRIPTOLIDE DERIVATIVE
(FR) DÉRIVÉ DE TRIPTOLIDE SUBSTITUÉ PAR DU FLUOR
(ZH) 一种氟代雷公藤内酯醇衍生物
Abstract: front page image
(EN)Provided is a compound represented by formula I, or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, polycrystalline material, or precursor thereof, and a manufacturing method and pharmaceutical application of same. The compound has improved immunosuppressive activity and antitumor activity, and has better development and application prospects.
(FR)L'invention concerne un composé représenté par la formule I, ou un sel pharmaceutiquement acceptable, un énantiomère, un diastéréomère, un tautomère, un solvate, un matériau polycristallin ou un précurseur de celui-ci, ainsi qu'un procédé de fabrication et une application pharmaceutique de celui-ci. Le composé présente une activité immunosuppressive et une activité antitumorale améliorées, et présente de meilleures perspectives de développement et d'application.
(ZH)提供一种如通式I所示的化合物、或其药学上可接受的盐、或其对映异构体、非对映异构体、互变异构体、溶剂化物、多晶型物或前药、其制备方法及在药学上的应用。所述化合物具有较佳的免疫抑制活性和抗肿瘤活性,具有较好的开发及应用前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)