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1. (WO2018019204) AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY

Pub. No.:    WO/2018/019204    International Application No.:    PCT/CN2017/094102
Publication Date: Fri Feb 02 00:59:59 CET 2018 International Filing Date: Tue Jul 25 01:59:59 CEST 2017
IPC: C07D 403/04
C07D 471/04
A61K 31/506
A61P 35/00
A61P 35/02
Applicants: SHENZHEN TARGETRX, INC.
深圳市塔吉瑞生物医药有限公司
Inventors: WANG, Yihan
王义汉
REN, Xingye
任兴业
JIN, Jian
金剑
LI, Huanyin
李焕银
AI, Yixin
艾义新
Title: AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY
Abstract:
An amino pyrimidine compound for inhibiting protein tyrosine kinase activity, a pharmaceutical composition thereof, preparation therefor, and an application thereof. Specifically, an amino pyrimidine compound represented by formula (I), R1, R2, L, Y, R6, W, A, m, and n being defined in the specification, and a pharmaceutically acceptable salt, a stereoisomer, a solvent compound, a hydrate, a polymorphism, a prodrug, or an isotope variant thereof. The compound can be used for treating and/or preventing protein tyrosine kinase-related diseases such as cell proliferative diseases, cancers, and immune diseases.