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1. (WO2018017996) IDENTIFICATION AND PRODUCTION OF HIGH AFFINITY IGM ANTIBODIES AND DERIVATIVES THEREOF
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/017996 International Application No.: PCT/US2017/043358
Publication Date: 25.01.2018 International Filing Date: 21.07.2017
IPC:
G01N 33/68 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/564 (2006.01) ,A61K 39/015 (2006.01) ,A61K 39/395 (2006.01) ,C07K 16/42 (2006.01) ,C07K 14/445 (2006.01) ,C07K 14/705 (2006.01) ,C07K 16/20 (2006.01)
Applicants: UNIVERSITY OF WASHINGTON[US/US]; 4545 Roosevelt Way NE, Suite 400 Seattle, Washington 98105, US
SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE[US/US]; 1900 Ninth Avenue Seattle, Washington 98101, US
Inventors: PEPPER, Marion; US
KRISHNAMURTY, Akshay; US
RAWLINGS, David J.; US
THOUVENEL, Christopher; US
Agent: FITZGERALD, Mark, J.; US
RESNICK, David S.; US
EISENSTEIN, Ronald I.; US
BENN, Susanna C.; US
BRAICH, Ravinderjit S.; US
KARTTUNEN CONTARINO, Leena H.; US
CROSBY, David F.; US
HUFF, Shayne Y.; US
MILLS, Tari W.; US
PTASHKA, Teresa A.; US
SUMMERFORD, Candace M.; US
HSU WHITE, Jane; US
KLING, Nicole D.; US
TSE, Janet M.; US
Priority Data:
62/365,51422.07.2016US
Title (EN) IDENTIFICATION AND PRODUCTION OF HIGH AFFINITY IGM ANTIBODIES AND DERIVATIVES THEREOF
(FR) IDENTIFICATION ET PRODUCTION D'ANTICORPS IGM À HAUTE AFFINITÉ ET DE LEURS DÉRIVÉS
Abstract: front page image
(EN) Provided herein are methods of sorting antigen-specific IgM memory B cells (MBCs), compositions and methods comprising such antigen-specific IgM MBCs, and recombinant antibody or antigen-binding fragments isolated from such antigen-specific IgM MBCs. As demonstrated herein, IgM+ and IgD+ MBCs are unique populations of cells with distinct phenotypic, functional and survival properties. Accordingly, the antigen-specific IgM MBCs and antibodies and antigen-binding fragments derived from these cells described herein are useful in therapeutic applications in vaccine strategies and treatment of infectious diseases.
(FR) L'invention concerne des procédés de tri de lymphocytes B mémoire (LBM) IgM spécifiques de l'antigène, des compositions et des procédés comprenant de tels LBM IgM spécifiques de l'antigène, et des anticorps de recombinaison ou des fragments de liaison à l'antigène isolés à partir de ces LBM IgM spécifiques de l'antigène. Comme le montre la présente invention, les LBM IgM+ et IgD+ constituent des populations uniques de cellules présentant des propriétés phénotypiques, fonctionnelles et de survie distinctes. En conséquence, les LBM IgM spécifiques de l'antigène et les anticorps et les fragments de liaison à l'antigène dérivés de ces cellules sont utiles dans des applications thérapeutiques s'inscrivant dans des stratégies vaccinales et pour le traitement de maladies infectieuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)