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1. (WO2018017865) INHIBITING MICRORNA TO PREVENT DEVELOPMENT OF ESSENTIAL HYPERTENSION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/017865    International Application No.:    PCT/US2017/043130
Publication Date: 25.01.2018 International Filing Date: 20.07.2017
IPC:
C07H 21/04 (2006.01), C12N 15/113 (2010.01), C12N 15/11 (2006.01)
Applicants: THOMAS JEFFERSON UNIVERSITY [US/US]; 901 Walnut Street Innovation Pillar Philadelphia, Pennsylvania 19107 (US)
Inventors: VADIGEPALLI, Rajanikanth; (US).
DECICCO, Danielle; (US).
SCHWABER, James; (US)
Agent: VOS STRACHE, Kyle; (US)
Priority Data:
62/364,616 20.07.2016 US
Title (EN) INHIBITING MICRORNA TO PREVENT DEVELOPMENT OF ESSENTIAL HYPERTENSION
(FR) INHIBITION DE MICRO-ARN POUR PRÉVENIR LE DÉVELOPPEMENT DE L'HYPERTENSION ESSENTIELLE
Abstract: front page image
(EN)Therapeutic compositions and methods of treatment of the central nervous system, specifically towards hypertension comprising administration of a therapeutic comprising an anti-miR-135a, an anti-miR-miR-376a, or a combination, in the central nervous system effectively attenuates hypertension for up to four weeks provided a single administration.
(FR)Des compositions thérapeutiques et des méthodes de traitement du système nerveux central, spécifiquement envers l'hypertension comprenant l'administration d'un agent thérapeutique comprenant un anticorps anti-miR-135a, un anticorps anti-miR-376a, ou une combinaison, dans le système nerveux central atténue efficacement l'hypertension pour plus de quatre semaines fourni en une administration unique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)