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1. (WO2018017589) COMPOUNDS FOR TARGETING CANCER STEM CELLS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/017589 International Application No.: PCT/US2017/042630
Publication Date: 25.01.2018 International Filing Date: 18.07.2017
IPC:
A61K 31/343 (2006.01)
Applicants: THE GENERAL HOSPITAL CORPORATION[US/US]; 55 Fruit Street Boston, Massachusetts 02114, US
Inventors: GARKAVTSEV, Igor; US
JAIN, Rakesh K.; US
Agent: DAVEY, PH.D., Evan A.; US
FOLLETT, PH.D., Angela D.; US
Priority Data:
62/364,21519.07.2016US
62/483,58710.04.2017US
Title (EN) COMPOUNDS FOR TARGETING CANCER STEM CELLS
(FR) COMPOSÉS DE CIBLAGE DE CELLULES SOUCHES CANCÉREUSES
Abstract:
(EN) This invention relates to antagonists of G3BP2, G3BP1, and ZEB1. Pharmaceutical compositions comprising G3BP2 inhibitors, methods of inhibiting G3BP2, G3BP1, and ZEB1, methods of treating cancer and inflammation, and methods of identifying an inhibitor of cancer stems cells are also provided.
(FR) L'invention concerne des antagonistes de G3BP2, G3BP1 et ZEB1. L'invention concerne également des compositions pharmaceutiques comprenant des inhibiteurs de G3BP2, des procédés d'inhibition de G3BP2, G3BP1 et ZEB1, des procédés de traitement de cancer et d'inflammation, et des procédés d'identification d'un inhibiteur de cellules souches cancéreuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)