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1. (WO2018017410) COMBINATION THERAPY OF ABEMACICLIB AND A PI3 KINASE/MTOR DUAL INHIBITOR FOR USE IN THE TREATMENT OF BREAST CANCER
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/017410 International Application No.: PCT/US2017/042104
Publication Date: 25.01.2018 International Filing Date: 14.07.2017
IPC:
A61K 31/444 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/565 (2006.01) ,A61P 35/00 (2006.01)
Applicants: ELI LILLY AND COMPANY[US/US]; Lilly Corporate Center Indianapolis, Indiana 46285, US
Inventors: BECKMANN, Richard Paul; US
DONOHO, Gregory Paul; US
WACHECK, Volker; US
Agent: DINGESS-HAMMOND, Elizabeth A.; US
BARRETT, Brian P.; US
Priority Data:
62/365,61722.07.2016US
Title (EN) COMBINATION THERAPY OF ABEMACICLIB AND A PI3 KINASE/MTOR DUAL INHIBITOR FOR USE IN THE TREATMENT OF BREAST CANCER
(FR) POLYTHÉRAPIE À BASE D'ABEMACICLIB ET D'UN INHIBITEUR DOUBLE DE KINASE PI3 /MTOR, DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT DU CANCER DU SEIN
Abstract:
(EN) The present invention relates to a dual combination of abemaciclib and a PI3 kinase/MTOR dual inhibitor known in the art as LY3023414, and a triple combination which also adds fulvestant, and to methods of using the dual and triple combinations to treat patients with certain disorders, such as in patients with breast cancer, in particular patients with locally advanced breast cancer or metastatic breast cancer.
(FR) La présente invention concerne une combinaison double d'abemaciclib et d'un inhibiteur double de kinase PI3/MTOR connu dans l'art sous le nom LY3023414, et une triple combinaison qui ajoute également du fulvestrant, et sur des procédés d'utilisation des combinaisons doubles et triples pour traiter des patients souffrant de certains troubles, tels que chez des patients souffrant d'un cancer du sein, en particulier des patients souffrant d'un cancer du sein localement avancé ou métastatique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)