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1. (WO2018016917) RECOMBINANT VACCINIA VIRUS AND USE THEREOF

Pub. No.:    WO/2018/016917    International Application No.:    PCT/KR2017/007896
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Sat Jul 22 01:59:59 CEST 2017
IPC: C12N 7/00
A61K 35/768
Applicants: KOLON LIFE SCIENCE, INC.
코오롱생명과학 주식회사
Inventors: KIM, Sujeong
김수정
KIM, Minjung
김민정
CHOI, Heonsik
최헌식
SHIN, Jaeil
신재일
KIM, Minju
김민주
LEE, Hyesun
이혜선
LEE, Soondong
이순동
CHOI, Hwanjun
최환준
KIM, Joonsung
김준성
HONG, Jieun
홍지은
LEE, Eunjin
이은진
Title: RECOMBINANT VACCINIA VIRUS AND USE THEREOF
Abstract:
The present invention relates to a recombinant vaccinia virus in which the expression of some genes is inhibited, and a use thereof. The recombinant vaccinia virus of the present invention selectively kills cancer cells, and has an excellent reproducibility in cancer cells. Also, the virus has a lower toxicity to normal cells, and thus has an advantage of being safe for a human body. Therefore, the recombinant vaccinia virus of the present invention can be effectively used as a composition for treating cancer.