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1. (WO2018016826) COMPOSITION CONTAINING 3-O-GALLOYL-3,3',5,5',7-PENTAHYDROXYFLAVAN FOR IMPROVING COGNITIVE FUNCTION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/016826 International Application No.: PCT/KR2017/007664
Publication Date: 25.01.2018 International Filing Date: 17.07.2017
IPC:
A61K 31/352 (2006.01) ,A61K 31/12 (2006.01) ,A23L 33/10 (2016.01)
Applicants: AMOREPACIFIC CORPORATION[KR/KR]; 106, Hangang-daero, Yongsan-gu, Seoul 04386, KR
Inventors: HONG, Yong-Deog; KR
CHOI, Minsik; KR
CHO, Si Young; KR
KIM, Jeong-Kee; KR
Agent: KIM, Sun-young; KR
Priority Data:
10-2016-009076518.07.2016KR
10-2017-008944914.07.2017KR
Title (EN) COMPOSITION CONTAINING 3-O-GALLOYL-3,3',5,5',7-PENTAHYDROXYFLAVAN FOR IMPROVING COGNITIVE FUNCTION
(FR) COMPOSITION CONTENANT DU 3-O-GALLOYL-3,3',5,5',7-PENTAHYDROXYFLAVANE POUR AMÉLIORER LA FONCTION COGNITIVE
(KO) 3-O-갈로일-3,3',5,5',7-펜타하이드록시플라반을 포함하는 인지 기능 개선용 조성물
Abstract: front page image
(EN) The present invention relates to, in one aspect, a composition containing post-fermented tea ketone extract as an active ingredient for improving cognitive function, and, in another aspect, to a composition containing 3-O-galloyl-3,3',5,5',7-pentahydroxyflavan isolated from the post-fermented tea ketone extract, or an isomer, acceptable salt, prodrug, hydrate or solvate thereof as an active ingredient for improving cognitive function. By means of one aspect of the present invention, the aggregation of ß-amyloid can be effectively suppressed, and expressions of BDNF and DNMT1 can be controlled, and thus the present invention, in one aspect, is expected to be effectively applied in a variety of fields associated with decline in cognitive function.
(FR) La présente invention concerne, selon un aspect, une composition contenant un extrait de cétone de thé post-fermenté en tant qu'ingrédient actif pour améliorer la fonction cognitive, et, dans un autre aspect, une composition contenant du 3-O-galloyl-3,3',5,5',7-pentahydroxyflavane isolé de l'extrait de cétone de thé post-fermenté, ou un isomère, un sel acceptable, un promédicament, un hydrate ou un solvate de celui-ci en tant qu'ingrédient actif pour améliorer la fonction cognitive. Selon un aspect de la présente invention, l'agrégation de la ß-amyloïde peut être efficacement supprimée, et les expressions de BDNF et DNMT1 peuvent être contrôlées, ainsi, selon un aspect, on prévoit une application efficace de la présente invention dans une variété de domaines associés au déclin de la fonction cognitive.
(KO) 본 발명은 일 측면에서 후발효차 케톤 분획물을 유효성분으로 포함하는 인지기능 저하 개선용 조성물에 관한 것이고, 다른 측면에서 후발효차 케톤 분획물로부터 분리한 3-O-갈로일-3,3',5,5',7-펜타하이드록시플라반 (3-O-galloyl-3,3',5,5',7-pentahydroxyflavan), 이의 이성질체, 이의 약학적으로 허용가능한 염, 이의 프로드럭, 이의 수화물, 또는 이의 용매화물을 유효성분으로 포함하는 인지기능 저하 개선용 조성물에 관한 것이며, 본 발명의 일 측면을 이용하여 베타-아밀로이드의 응집을 효과적으로 억제할 수 있고, BDNF 발현 및 DNMT1 발현을 조절할 수 있으므로, 본 발명은 일 측면에서 인지기능 저하와 관련된 다양한 분야에 활용될 수 있을 것이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)