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1. (WO2018016523) NOVEL RADIOPROTECTANT

Pub. No.:    WO/2018/016523    International Application No.:    PCT/JP2017/026101
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Thu Jul 20 01:59:59 CEST 2017
IPC: A61K 31/445
A61K 31/4523
A61K 31/4535
A61K 31/4709
A61P 35/00
A61P 39/00
A61P 43/00
Applicants: NAGASAKI UNIVERSITY
国立大学法人 長崎大学
Inventors: UEDA, Hiroshi
植田 弘師
DEGUCHI, Yuichi
出口 雄一
NAGAI, Jun
永井 潤
MIZUTA, Satoshi
水田 賢志
SUZUKI, Keiji
鈴木 啓司
MATSUSHITA, Yosuke
松下 洋輔
SAKAI, Yuki
酒井 佑宜
Title: NOVEL RADIOPROTECTANT
Abstract:
Provided is a novel radioprotectant that comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient [in formula (I): a ring A represents a fused ring; and R1 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms]. In particular, provided is a radioprotectant that comprises a compound represented by formula (A) or (B) as an active ingredient. The radioprotectant according to the present invention reduces cell damage and cell death caused by radiation exposure and exhibits an effect of protecting immune-related cells.