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1. (WO2018015677) METHOD FOR THE RESOLUTION OF BACLOFEN SALTS

Pub. No.:    WO/2018/015677    International Application No.:    PCT/FR2017/051992
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Fri Jul 21 01:59:59 CEST 2017
IPC: C07C 229/34
Applicants: UNIVERSITE DE ROUEN
Inventors: COQUEREL, Gérard
MAHIEUX, Julien
GENDRON, François-Xavier
Title: METHOD FOR THE RESOLUTION OF BACLOFEN SALTS
Abstract:
The invention relates to the field of resolution of chiral compounds existing in the form of two optical antipodes (enantiomers), such as Baclofen. More particularly, the invention relates to the production of the pure enantiomer (R)(-) Baclofen, of chemical nomenclature (R)-4-amino-3-(4-chlorophenyl)-butanoic acid, and the hydrogen maleate salt thereof. More specifically, the invention relates to the resolution of hydrogen maleate salts of racemic Baclofen by preferential crystallisation and particularly by the AS3PC method (auto-seeded and programmed polythermal preferential crystallisation).