Search International and National Patent Collections

1. (WO2018015551) METHODS FOR DISCRIMINATING A TOLERANT SUBJECT

Pub. No.:    WO/2018/015551    International Application No.:    PCT/EP2017/068517
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Sat Jul 22 01:59:59 CEST 2017
IPC: C12Q 1/68
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
UNIVERSITÉ DE NANTES
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors: DANGER, Richard
BROUARD, Sophie
GIRAL, Magali
RAMSTEIN, Gérard
Title: METHODS FOR DISCRIMINATING A TOLERANT SUBJECT
Abstract:
The present invention relates to a method for discriminating an operationally tolerant (TOL) subject from a non-operationally tolerant (STA) subject, comprising the following steps: i) establishing a composite score of tolerance (cSoT) with the expression levels of six genes in a biological sample obtained from said subject and two clinical parameters; wherein said six genes are ID3, AKR1C3, CD40, CTLA4, TCL1A and MZB1, and wherein said cSoT is established by the following formula: (I), ii) comparing this cSoT with a predetermined reference value; and iii) concluding that the subject is TOL when the cSoT is higher than the predetermined reference value or concluding that the subject is STA when the cSoT is lower than the predetermined reference value.