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1. (WO2018015546) COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
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Pub. No.: WO/2018/015546 International Application No.: PCT/EP2017/068500
Publication Date: 25.01.2018 International Filing Date: 21.07.2017
IPC:
A61K 51/04 (2006.01) ,C07B 59/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
Applicants:
AC IMMUNE S.A. [CH/CH]; EPFL Innovation Park, Building B 1015 Lausanne, CH
PIRAMAL IMAGING SA [CH/CH]; Route de l'Ecole 13 1753 Matran, CH
Inventors:
KROTH, Heiko; CH
MOLETTE, Jérôme; FR
SCHIEFERSTEIN, Hanno; DE
MÜLLER, Andre; DE
SCHMITT-WILLICH, Heribert; DE
BERNDT, Mathias; DE
ODEN, Felix; DE
Agent:
VOSSIUS & PARTNER; Siebertstraße 3 81675 München, DE
Priority Data:
16180905.822.07.2016EP
Title (EN) COMPOUNDS FOR IMAGING TAU PROTEIN AGGREGATES
(FR) COMPOSÉS POUR L'IMAGERIE D'AGRÉGATS DE PROTÉINES TAU
Abstract:
(EN) The present invention relates to novel compounds of the formula (I) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.
(FR) La présente invention concerne de nouveaux composés de la formule (I) qui peuvent être utilisés dans la détection sélective de tau dans les troubles et les anomalies associés à des agrégats de tau comme la maladie d'alzheimer et autres tauopathies, à l'aide d'une technique d'imagerie de type tomographie par émission de positrons (PET).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)