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1. (WO2018015535) EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.:    WO/2018/015535    International Application No.:    PCT/EP2017/068476
Publication Date: 25.01.2018 International Filing Date: 21.07.2017
IPC:
A61K 39/395 (2006.01)
Applicants: EVOX THERAPEUTICS LTD [GB/GB]; 2nd Floor King Charles House Park End Street Oxford OX1 1JD (GB)
Inventors: WIKLANDER, Oscar; (SE).
GÖRGENS, André; (SE).
GUPTA, Dhanu; (SE)
Agent: COOLEY (UK) LLP; Dashwood 69 Old Broad Street London, Greater London EC2M 1QS (GB)
Priority Data:
1612643.5 21.07.2016 GB
Title (EN) EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY
(FR) VÉSICULE EXTRACELLULAIRE COMPRENANT UNE PROTÉINE DE FUSION AYANT UNE CAPACITÉ DE LIAISON DE FC
Abstract: front page image
(EN)The present invention pertains to extracellular vesicle (EV) therapeutics, wherein the EVs are coated with proteins containing Fc domains (such as antibodies) for i.a. targeting and therapeutic applications. The coating of EVs is achieved through inventive protein engineering of EV polypeptides. The present invention thus relates to methods for coating of EVs, EVs per se, as well as pharmaceutical compositions and medical applications of such EVs coated with Fc containing proteins.
(FR)La présente invention concerne des agents thérapeutiques à base de vésicules extracellulaires (EV), les EV étant enrobées de protéines contenant des domaines Fc (tels que des anticorps) pour, entre autres, des applications de ciblage et thérapeutiques. L’enrobage des EV est obtenu au moyen de l'ingénierie des protéines des polypeptides EV de l'invention. Par conséquent, l’invention concerne des procédés d’enrobage d'EV, des EV en tant que tels, ainsi que des compositions pharmaceutiques et des applications médicales de telles EV enrobées de protéines contenant Fc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)