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1. (WO2018015535) EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY

Pub. No.:    WO/2018/015535    International Application No.:    PCT/EP2017/068476
Publication Date: Fri Jan 26 00:59:59 CET 2018 International Filing Date: Sat Jul 22 01:59:59 CEST 2017
IPC: A61K 39/395
Applicants: EVOX THERAPEUTICS LTD
Inventors: WIKLANDER, Oscar
GÖRGENS, André
GUPTA, Dhanu
Title: EXTRACELLULAR VESICLE COMPRISING A FUSION PROTEIN HAVING FC BINDING CAPACITY
Abstract:
The present invention pertains to extracellular vesicle (EV) therapeutics, wherein the EVs are coated with proteins containing Fc domains (such as antibodies) for i.a. targeting and therapeutic applications. The coating of EVs is achieved through inventive protein engineering of EV polypeptides. The present invention thus relates to methods for coating of EVs, EVs per se, as well as pharmaceutical compositions and medical applications of such EVs coated with Fc containing proteins.